Research Paper Volume 13, Issue 8 pp 11381—11410

Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma

Two clusters in the TCGA LUAD cohort with distinct clinical outcomes and clinicopathological features identified by consensus clustering. (A) Consensus clustering matrix at k=2. (B) Tracking plot at k=2 to k=10 by consensus clustering. (C) Heatmap of interferon gamma response gene expression for two clusters (1 and 2) based on consensus clustering of TCGA LUAD tumor samples, together with the clinical and pathological features (T, N, M, or stage). (D) Principal component analysis (PC1 vs. PC2) of 24 interferon gamma response gene expression pattern in the TCGA LUAD cohort. Two clusters are marked with colors (green and red). (E) Kaplan-Meier overall survival rate curves for two clusters in the TCGA LUAD cohorts. P=0.002 (group 1 vs. group 2).

Figure 3. Two clusters in the TCGA LUAD cohort with distinct clinical outcomes and clinicopathological features identified by consensus clustering. (A) Consensus clustering matrix at k=2. (B) Tracking plot at k=2 to k=10 by consensus clustering. (C) Heatmap of interferon gamma response gene expression for two clusters (1 and 2) based on consensus clustering of TCGA LUAD tumor samples, together with the clinical and pathological features (T, N, M, or stage). (D) Principal component analysis (PC1 vs. PC2) of 24 interferon gamma response gene expression pattern in the TCGA LUAD cohort. Two clusters are marked with colors (green and red). (E) Kaplan-Meier overall survival rate curves for two clusters in the TCGA LUAD cohorts. P=0.002 (group 1 vs. group 2).