Research Paper Volume 13, Issue 8 pp 11381—11410

Seven interferon gamma response genes serve as a prognostic risk signature that correlates with immune infiltration in lung adenocarcinoma

Validation of seven-gene risk signature in an independent LUAD cohort. (A) Kaplan-Meier curves of overall survival of the high or low risk group in the GSE72094 cohort. (B) Risk score distribution in the GSE72094 cohort. (C) Survival time and survival status distribution in the GSE72094 cohort. (D) Heatmap showing the expression level of seven interferon gamma response genes in the low or high risk group in the GSE72094 cohort. Association of various clinical features with two groups (high vs. low risk) were determined. *PE, F) Univariate (E) and multivariate (F) Cox regression analysis of the association between clinical features (gender, age, stage, KRAS or LKB1 mutation), risk score, and patient overall survival in the GSE72094 cohort. Hazard ratio and associated p value are shown. (G) ROC curves for 3-year survival prediction and clinical characteristics, including age, gender, stage, KRAS or LKB1 mutation in the GSE72094 cohort.

Figure 7. Validation of seven-gene risk signature in an independent LUAD cohort. (A) Kaplan-Meier curves of overall survival of the high or low risk group in the GSE72094 cohort. (B) Risk score distribution in the GSE72094 cohort. (C) Survival time and survival status distribution in the GSE72094 cohort. (D) Heatmap showing the expression level of seven interferon gamma response genes in the low or high risk group in the GSE72094 cohort. Association of various clinical features with two groups (high vs. low risk) were determined. *P<0.05, **P<0.01 and ***P<0.001. (E, F) Univariate (E) and multivariate (F) Cox regression analysis of the association between clinical features (gender, age, stage, KRAS or LKB1 mutation), risk score, and patient overall survival in the GSE72094 cohort. Hazard ratio and associated p value are shown. (G) ROC curves for 3-year survival prediction and clinical characteristics, including age, gender, stage, KRAS or LKB1 mutation in the GSE72094 cohort.