Research Paper Volume 13, Issue 8 pp 11411—11432

Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation

TGLQ inhibited protein expression of HSP90 and TLR4 in ox-LDL induced macrophages. (A, B) represent the protein expression levels of HSP90 and TLR4 detected by western blot, respectively, in each group. (C) represents data shown in Figure 11A, 11B. Unlike the macrophages of the control group, the macrophages of the model group, the low-dose TGLQ-serum (LTGLQ) group and the high-dose TGLQ-serum (HTGLQ) group were exposed to 60μg/ml oxidized-LDL (ox-LDL) for 24 h. In addition, control serum, 5% TGLQ serum and 20% TGLQ serum were added to the model group, the LTGLQ group and the HTGLQ group, respectively. #, ##, and ### represent P P P P P P P P

Figure 11. TGLQ inhibited protein expression of HSP90 and TLR4 in ox-LDL induced macrophages. (A, B) represent the protein expression levels of HSP90 and TLR4 detected by western blot, respectively, in each group. (C) represents data shown in Figure 11A, 11B. Unlike the macrophages of the control group, the macrophages of the model group, the low-dose TGLQ-serum (LTGLQ) group and the high-dose TGLQ-serum (HTGLQ) group were exposed to 60μg/ml oxidized-LDL (ox-LDL) for 24 h. In addition, control serum, 5% TGLQ serum and 20% TGLQ serum were added to the model group, the LTGLQ group and the HTGLQ group, respectively. #, ##, and ### represent P < 0.05, P < 0.01, and P < 0.001 respectively, in comparison with the control group. *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001 respectively, in comparison with the model group. % and %%% represent P < 0.05 and P < 0.001 respectively, in comparison with the LTGLQ group.