Research Paper Volume 13, Issue 8 pp 11411—11432

Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation

The underlying mechanisms of TGLQ treatment of AS, via network analysis. Illustration of the relevance among herbs of TGLQ, their key targets for AS therapy, pathways involved in these key TGLQ targets and the corresponding pharmacological actions. Yellow nodes refer to the ten herbs contained in TGLQ; Red nodes refer to the key targets; Purple nodes refer to the signalling pathways; Green nodes refer to the pharmacological actions. Green lines refer to the relations between the pharmacological actions and the signalling pathways. Purple lines refer to the relations between the signalling pathways and the key targets. Grey lines refer to the relations between the key targets and ten herbs.

Figure 4. The underlying mechanisms of TGLQ treatment of AS, via network analysis. Illustration of the relevance among herbs of TGLQ, their key targets for AS therapy, pathways involved in these key TGLQ targets and the corresponding pharmacological actions. Yellow nodes refer to the ten herbs contained in TGLQ; Red nodes refer to the key targets; Purple nodes refer to the signalling pathways; Green nodes refer to the pharmacological actions. Green lines refer to the relations between the pharmacological actions and the signalling pathways. Purple lines refer to the relations between the signalling pathways and the key targets. Grey lines refer to the relations between the key targets and ten herbs.