Research Paper Volume 13, Issue 8 pp 11470—11490

Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1

Downregulation of miR-1a prevents statin-induced morphological deterioration of gastrocnemius in ApoE-/- mice. (A) The protocol for animal experiments was shown. (B) The morphology of gastrocnemius muscle was observed by HE staining. (C) Quantitative analysis of fibre cross-sectional area (CSA) in gastrocnemius muscle from mice was performed. N is 10-15 in each group. **P ##Ppost-hoc tests was used to determine P value in (C).

Figure 6. Downregulation of miR-1a prevents statin-induced morphological deterioration of gastrocnemius in ApoE-/- mice. (A) The protocol for animal experiments was shown. (B) The morphology of gastrocnemius muscle was observed by HE staining. (C) Quantitative analysis of fibre cross-sectional area (CSA) in gastrocnemius muscle from mice was performed. N is 10-15 in each group. **P < 0.01 vs. vehicle group. ##P<0.01 vs. statin alone. A one-way ANOVA followed by Tukey post-hoc tests was used to determine P value in (C).