Research Paper Volume 13, Issue 8 pp 11507—11527

A novel comprehensive immune-related gene signature as a promising survival predictor for the patients with head and neck squamous cell carcinoma

The regulatory network of TF and univariate cox analysis of differentially expressed IRGs and OS of HNSCC. (A) The regulatory network constructed based on prognosis-related IRGs and TFs. The red circle represents the high-risk IRGs and the green circular represents the low-risk IRGs. The triangle represents differentially expressed TFs. The red link line represents positive regulation, while there was no observed negative regulation. (B) A total of 24 differentially expressed IRGs found to be significantly associated with the OS of HNSCC patients (p-value

Figure 2. The regulatory network of TF and univariate cox analysis of differentially expressed IRGs and OS of HNSCC. (A) The regulatory network constructed based on prognosis-related IRGs and TFs. The red circle represents the high-risk IRGs and the green circular represents the low-risk IRGs. The triangle represents differentially expressed TFs. The red link line represents positive regulation, while there was no observed negative regulation. (B) A total of 24 differentially expressed IRGs found to be significantly associated with the OS of HNSCC patients (p-value < 0.01). Red points represent positive correlations, while green points represent negative correlations.