The association between our prognostic signature and HPV, T stage, TNM stage and recurrence. (A) The HPV-positive patients exhibited a lower risk score compared with HPV-negative patients (p = 6.842 x 10-5). (B) The immune-related signature risk scores for T3 and 4 stage HNSCC patients were notably higher compared with that of T1 and 2 patients (p = 0.005). (C) The immune-related signature risk scores for stage III & IV HNSCC patients were notably higher compared with that of stage I & II patients (p = 0.032). (D) Patients with recurrence of HNSCC have higher risk scores compared with those having no recurrence (p = 0.002).