Research Paper Volume 13, Issue 7 pp 10688—10702

Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels

OIP5-AS1 promotes migration and invasion by targeting the miR-186-5p/NGFR axis. (A, B) Level of OIP5-AS1 and miR-186-5p protein after transfection. (C, D) Comparison of cell viability in each group. (E, F) Comparison of the migration and invasion abilities of Panc-1 cells in different groups. (G, H) Comparison of the migration and invasion abilities of Capan-1 cells in different groups. (I–L) Comparison of the NGFR mRNA and p75NTR protein levels in each group.

Figure 6. OIP5-AS1 promotes migration and invasion by targeting the miR-186-5p/NGFR axis. (A, B) Level of OIP5-AS1 and miR-186-5p protein after transfection. (C, D) Comparison of cell viability in each group. (E, F) Comparison of the migration and invasion abilities of Panc-1 cells in different groups. (G, H) Comparison of the migration and invasion abilities of Capan-1 cells in different groups. (IL) Comparison of the NGFR mRNA and p75NTR protein levels in each group.