Research Paper Volume 13, Issue 7 pp 10688—10702

Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels

OIP5-AS1 regulates the role of proNGF in promoting cell migration and invasion by targeting the miR-186-5p/NGFR axis. (A) Comparison of the tumour weight of mice in each group. (B, C) OIP5-AS1, miR-186-5p, NGFR mRNA and p75NTR protein levels of tumour tissues in each group. (D) Comparison of the tumour weight of mice in each group. (E, F) Levels of miR-186-5p, NGFR and proNGF mRNA, and p75NTR and proNGF proteins in the tumour tissues of each group.

Figure 8. OIP5-AS1 regulates the role of proNGF in promoting cell migration and invasion by targeting the miR-186-5p/NGFR axis. (A) Comparison of the tumour weight of mice in each group. (B, C) OIP5-AS1, miR-186-5p, NGFR mRNA and p75NTR protein levels of tumour tissues in each group. (D) Comparison of the tumour weight of mice in each group. (E, F) Levels of miR-186-5p, NGFR and proNGF mRNA, and p75NTR and proNGF proteins in the tumour tissues of each group.