Research Paper Volume 13, Issue 8 pp 11542—11563

HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation

HucMSC-ex protect skin cell from oxidative stress in vivo. (A) Representative images of skin appearance and H&E staining after hucMSC-ex treatment 72 hours significantly inhibited skin inflammation and accelerated skin cell renewal (n=5). Original magnification (100x). (B) p-NF-κB and PCNA expression level quantified by western blot. (C, D): Immunofluorescence and immunohistochemical staining analysis of cutaneous tissues γH2AX and 8-OHDG expression level, Original magnification (200x).

Figure 2. HucMSC-ex protect skin cell from oxidative stress in vivo. (A) Representative images of skin appearance and H&E staining after hucMSC-ex treatment 72 hours significantly inhibited skin inflammation and accelerated skin cell renewal (n=5). Original magnification (100x). (B) p-NF-κB and PCNA expression level quantified by western blot. (C, D): Immunofluorescence and immunohistochemical staining analysis of cutaneous tissues γH2AX and 8-OHDG expression level, Original magnification (200x).