Research Paper Volume 13, Issue 8 pp 11629—11645

Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma

Hsa

Figure 8. Hsa_circ_0072309 promoted tumorigenesis through the miR-607/FTO axis in NSCLC. (A) A representative image of the tumor volume of control and hsa_circ_0072309-KD H1975 cells with or without FTO overexpression (n = 5). (B) Measurement of subcutaneous tumor growth of control and hsa_circ_0072309-KD H1975 cells with or without FTO overexpression (n = 5, two-way ANOVA followed by Tukey’s multiple comparisons test. (C) Subcutaneous tumors were excised and weighed after mice were sacrificed (n = 5, one-way ANOVA followed by Tukey’s multiple comparisons test). (D) H&E and FTO staining of subcutaneous tumors of control and hsa_circ_0072309-KD H1975 cells with or without FTO overexpression. *p < 0.05, **p < 0.01. Scale bars: 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001.