Research Paper Volume 13, Issue 8 pp 11678—11695

Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function

Structure and function of retina in wild type and Piccolo-/- mouse. (A) Eyes from wild type (WT) and Piccolo-/- mice. (B) Mean diameters of eyeballs from WT (n = 8) and Piccolo-/- (n = 8) mice. (C) ERG recording a-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at P30. (D) ERG recording b-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at P30. (E) ERG recording a-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at 4 months. (F) ERG recording b-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at 4 months. The asterisk indicates a significant difference between WT and Piccolo-/- mice. *P

Figure 3. Structure and function of retina in wild type and Piccolo-/- mouse. (A) Eyes from wild type (WT) and Piccolo-/- mice. (B) Mean diameters of eyeballs from WT (n = 8) and Piccolo-/- (n = 8) mice. (C) ERG recording a-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at P30. (D) ERG recording b-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at P30. (E) ERG recording a-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at 4 months. (F) ERG recording b-wave amplitudes from WT (n=6) and Piccolo-/- (n=6) mice at 4 months. The asterisk indicates a significant difference between WT and Piccolo-/- mice. *P < 0.05, **P < 0.01, by two-tailed Student’s t test. Error bars = Mean ± SD.