Research Paper Volume 13, Issue 10 pp 13560—13570

Methylation factor MRPL15 identified as a potential biological target in Alzheimer’s disease

Molecular changes in the progression of Alzheimer’s disease. (A) The differentially expressed genes between moderate and mild AD patients. (B) Differentially expressed genes between severe and moderate AD patients. (C) Modules significantly up or down in the STEM results. (D) The trend in gene expression in significantly up-regulated or down-regulated modules. (E) The expression trend of potential risk genes in different stages of AD in patients. The enrichment results of persistent disorder genes include biological function (F) and the KEGG pathway (G).

Figure 3. Molecular changes in the progression of Alzheimer’s disease. (A) The differentially expressed genes between moderate and mild AD patients. (B) Differentially expressed genes between severe and moderate AD patients. (C) Modules significantly up or down in the STEM results. (D) The trend in gene expression in significantly up-regulated or down-regulated modules. (E) The expression trend of potential risk genes in different stages of AD in patients. The enrichment results of persistent disorder genes include biological function (F) and the KEGG pathway (G).