Research Paper Volume 13, Issue 6 pp 8026—8039

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Boxplot representation of the normalized and KCN-insensitive-corrected oxygen consumption rates measured in peripheral blood mononuclear cells (PBMC) from patients treated with calcineurin inhibitor (CNi) or CNi + mTOR inhibitor (CNi+mTORi) under resting conditions (RR, A), in the presence of oligomycin (OL, B) and in the presence of valinomycin (VAL, C). Statistical difference was assessed by unpaired student’s t-test.

Figure 2. Boxplot representation of the normalized and KCN-insensitive-corrected oxygen consumption rates measured in peripheral blood mononuclear cells (PBMC) from patients treated with calcineurin inhibitor (CNi) or CNi + mTOR inhibitor (CNi+mTORi) under resting conditions (RR, A), in the presence of oligomycin (OL, B) and in the presence of valinomycin (VAL, C). Statistical difference was assessed by unpaired student’s t-test.