Research Paper Volume 13, Issue 6 pp 8026—8039

mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Evaluation of pentraxin-3 and p21ink as markers of inflammaging in the two groups of kidney transplant recipients. The inhibition of mTOR pathways in group (B) was associated with reduced circulating levels of Pentraxin-3 (A) and down-regulation of p21 in PBMC (real-time PCR).

Figure 7. Evaluation of pentraxin-3 and p21ink as markers of inflammaging in the two groups of kidney transplant recipients. The inhibition of mTOR pathways in group (B) was associated with reduced circulating levels of Pentraxin-3 (A) and down-regulation of p21 in PBMC (real-time PCR).