Research Paper Volume 13, Issue 8 pp 11738—11751

Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models

Pink1-mediated mitophagy pathway implicated in the function of quercetin in PD rats. In each group, rats were rated for rotarod test (A), forelimb function (B), and apomorphine induced contralateral rotation (C) (*P n = 6 for each group, two-way ANOVA test followed by Bonferroni’s post hoc test). (D) The protein levels of a-synuclein and Parkin in different groups (n = 6 for each group). (E) Quantification of the a-synuclein protein level in each group. (F) Quantification of the Parkin protein level in each group. (G) The working model and potential mechanism of quercetin in the 6-OHDA-lesioned PD models. Data are expressed as mean ± SEM. *P

Figure 4. Pink1-mediated mitophagy pathway implicated in the function of quercetin in PD rats. In each group, rats were rated for rotarod test (A), forelimb function (B), and apomorphine induced contralateral rotation (C) (*P < 0.05 compared to the designated control, n = 6 for each group, two-way ANOVA test followed by Bonferroni’s post hoc test). (D) The protein levels of a-synuclein and Parkin in different groups (n = 6 for each group). (E) Quantification of the a-synuclein protein level in each group. (F) Quantification of the Parkin protein level in each group. (G) The working model and potential mechanism of quercetin in the 6-OHDA-lesioned PD models. Data are expressed as mean ± SEM. *P < 0.05 compared to the designated control (ANOVA followed by Dunnett's multiple-comparison post hoc tests).