Research Paper Volume 13, Issue 8 pp 11752—11761

5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats

Zileuton suppresses expression of NF-κB, LTB4, TNF-α, IL-1β and IL-6 after SAH. (A, B) Representative images and the quantitative analysis of NF-κB after SAH in rats treat with Zileuton with or without LY294002 (n = 6 per group). (C–F) Effect of Zileuton with or without LY29400 on expression of LTB4, TNF-α, IL-1β and IL-6 after SAH (n = 6 in each group). *P &P #P

Figure 3. Zileuton suppresses expression of NF-κB, LTB4, TNF-α, IL-1β and IL-6 after SAH. (A, B) Representative images and the quantitative analysis of NF-κB after SAH in rats treat with Zileuton with or without LY294002 (n = 6 per group). (CF) Effect of Zileuton with or without LY29400 on expression of LTB4, TNF-α, IL-1β and IL-6 after SAH (n = 6 in each group). *P < 0.05 vs sham group and &P < 0.05 vs SAH group, #P < 0.05 vs SAH + Zileuton group.