Research Paper Volume 13, Issue 8 pp 11752—11761

5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats

Zileuton suppresses neuronal apoptosis after SAH. (A, C, D) Effect of Zileuton with and without LY294002 on expression levels of pro-apoptotic Bax and anti-apoptotic Bcl-2 (n = 6 per group). *P &P #P B, E) TUNEL analysis of the effect of Zileuton with and without LY294002 on the incidence of apoptosis among neurons after SAH. Original magnification, 400×, n = 6 per group. *P &P #P

Figure 4. Zileuton suppresses neuronal apoptosis after SAH. (A, C, D) Effect of Zileuton with and without LY294002 on expression levels of pro-apoptotic Bax and anti-apoptotic Bcl-2 (n = 6 per group). *P < 0.05 vs sham group and &P < 0.05 vs SAH group, #P < 0.05 vs SAH + Zileuton group. (B, E) TUNEL analysis of the effect of Zileuton with and without LY294002 on the incidence of apoptosis among neurons after SAH. Original magnification, 400×, n = 6 per group. *P < 0.05 vs sham group and &P < 0.05 vs SAH group, #P < 0.05 vs SAH + Zileuton group.