Research Paper Volume 13, Issue 8 pp 11752—11761

5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats

Zileuton improves neurological scores, BBB permeability and brain water content after SAH. (A–C) Effect of Zileuton with and without LY294002 on the indicated neurological functions (A); water content in the left and right cortical hemispheres (LH and RH, respectively), brain stem (BS) and cerebellum (CB) (B); and BBB permeability in the same brain regions, as indicated by Evans blue extravasation (C) (n = 6 in each group). *P &P #P

Figure 5. Zileuton improves neurological scores, BBB permeability and brain water content after SAH. (AC) Effect of Zileuton with and without LY294002 on the indicated neurological functions (A); water content in the left and right cortical hemispheres (LH and RH, respectively), brain stem (BS) and cerebellum (CB) (B); and BBB permeability in the same brain regions, as indicated by Evans blue extravasation (C) (n = 6 in each group). *P < 0.05 vs sham group and &P < 0.05 vs SAH group, #P < 0.05 vs SAH + Zileuton group.