Research Paper Volume 13, Issue 8 pp 11808—11821

Exosomes derived from miR-1228 overexpressing bone marrow-mesenchymal stem cells promote growth of gastric cancer cells

Overexpression of miR-1228 inhibits MMP-14 upregulation-induced invasion and migration of gastric cancer cells. (A) The invasion of si-MMP-14 transfected cells was slowed down after co-culture, while that of sh-MMP-14 transfected cells was accelerated. The invasion of sh-MMP-14+miR-1228-mimics transfected cells had no difference from that of si-NC transfected cells. (B) After co-culture, the migration of si-MMP-14 transfected cells decreased while that of sh-MMP-14 transfected cells increased. bPvs. si-NC.

Figure 9. Overexpression of miR-1228 inhibits MMP-14 upregulation-induced invasion and migration of gastric cancer cells. (A) The invasion of si-MMP-14 transfected cells was slowed down after co-culture, while that of sh-MMP-14 transfected cells was accelerated. The invasion of sh-MMP-14+miR-1228-mimics transfected cells had no difference from that of si-NC transfected cells. (B) After co-culture, the migration of si-MMP-14 transfected cells decreased while that of sh-MMP-14 transfected cells increased. bP< 0.01 vs. si-NC.