Research Paper Volume 13, Issue 10 pp 13585—13614

Characterizing a long-term chronic heart failure model by transcriptomic alterations and monitoring of cardiac remodeling

Pathways enrichment associated with advanced heart failure. (A) WGCNA identified demonstrated 7 modules by average linkage clustering. (B) Gene Ontology analysis of genes in the green module, which were more correlated with advanced heart failure. (C) List of the four significantly up-regulated (marked red) and four down-regulated gene sets (marked green) associated with advanced heart failure enriched in GSEA analysis. (D–E) Enrichment plots of four significantly up-regulated and down-regulated pathways. (F) Heatmap of the enriched genes in the Integrin signaling pathway. (G) Heatmap of the enriched genes in the WNT signaling pathway. (H) Protein-protein interaction network of WNT signaling pathway and hub genes involved in this network.

Figure 2. Pathways enrichment associated with advanced heart failure. (A) WGCNA identified demonstrated 7 modules by average linkage clustering. (B) Gene Ontology analysis of genes in the green module, which were more correlated with advanced heart failure. (C) List of the four significantly up-regulated (marked red) and four down-regulated gene sets (marked green) associated with advanced heart failure enriched in GSEA analysis. (DE) Enrichment plots of four significantly up-regulated and down-regulated pathways. (F) Heatmap of the enriched genes in the Integrin signaling pathway. (G) Heatmap of the enriched genes in the WNT signaling pathway. (H) Protein-protein interaction network of WNT signaling pathway and hub genes involved in this network.