Research Paper Volume 13, Issue 8 pp 11822—11832

ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203

ITPKA inhibited the tumorigenicity of ovarian cancer. (A) Gross images of the tumors formed by OVCAR3 control cells and OVCAR3/Flag-ITPKA cells in nude mice. (B) Tumor weight as shown in (A). (C) Immunostaining was performed to examine Ki67 expression. (D) Statistical analysis of (C). (E) Expression of P53 and Flag-ITPKA in the tumors was examined via western blot. **P

Figure 3. ITPKA inhibited the tumorigenicity of ovarian cancer. (A) Gross images of the tumors formed by OVCAR3 control cells and OVCAR3/Flag-ITPKA cells in nude mice. (B) Tumor weight as shown in (A). (C) Immunostaining was performed to examine Ki67 expression. (D) Statistical analysis of (C). (E) Expression of P53 and Flag-ITPKA in the tumors was examined via western blot. **P < 0.01.