Research Paper Volume 13, Issue 6 pp 7800—7827

Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

Chronic APAP treatment at an infratherapeutic dose does not change body and liver weight. (A) Mean daily water consumption. (B) Body weight of mice throughout 8 months of APAP treatment. (C) Comparison of the body weight, liver weight and liver-to-body weight ratio of 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 17-21 mice per group). Statistical analysis was performed by Mann-Whitney test (A), ANOVA test for repeated-measures (B) and Kruskal-Wallis or Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test (C). ** P P vs. 2 m/o; ns vs. 14 m/o.

Figure 1. Chronic APAP treatment at an infratherapeutic dose does not change body and liver weight. (A) Mean daily water consumption. (B) Body weight of mice throughout 8 months of APAP treatment. (C) Comparison of the body weight, liver weight and liver-to-body weight ratio of 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 17-21 mice per group). Statistical analysis was performed by Mann-Whitney test (A), ANOVA test for repeated-measures (B) and Kruskal-Wallis or Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test (C). ** P < 0.01 and *** P < 0.001 vs. 2 m/o; ns vs. 14 m/o.