Figure 1. Chronic APAP treatment at an infratherapeutic dose does not change body and liver weight. (A) Mean daily water consumption. (B) Body weight of mice throughout 8 months of APAP treatment. (C) Comparison of the body weight, liver weight and liver-to-body weight ratio of 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 17-21 mice per group). Statistical analysis was performed by Mann-Whitney test (A), ANOVA test for repeated-measures (B) and Kruskal-Wallis or Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test (C). ** P < 0.01 and *** P < 0.001 vs. 2 m/o; ns vs. 14 m/o.