Research Paper Volume 13, Issue 6 pp 7800—7827

Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

Chronic APAP exposure ameliorates the effect of age in liver alterations. (A, C) Representative images (10X and 20X) of H&E (A) and Oil Red O (C) staining performed on various sections of livers from 2 m/o, 14 m/o and 14 m/o + APAP mice. (B) Steatosis NAS score, inflammation NAS score, and total NAS score. (D) Plasma ALT, AST and LDH levels from 2 m/o, 14 m/o and 14 m/o + APAP mice. Values are expressed in international units per liter (U/L). Data are represented as the mean ± S.E.M. (n = 6-18 mice per group). Statistical analysis was performed by one-way ANOVA or Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test. * P P P vs. 2 m/o; #P ##P vs. 14 m/o.

Figure 2. Chronic APAP exposure ameliorates the effect of age in liver alterations. (A, C) Representative images (10X and 20X) of H&E (A) and Oil Red O (C) staining performed on various sections of livers from 2 m/o, 14 m/o and 14 m/o + APAP mice. (B) Steatosis NAS score, inflammation NAS score, and total NAS score. (D) Plasma ALT, AST and LDH levels from 2 m/o, 14 m/o and 14 m/o + APAP mice. Values are expressed in international units per liter (U/L). Data are represented as the mean ± S.E.M. (n = 6-18 mice per group). Statistical analysis was performed by one-way ANOVA or Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test. * P < 0.05, ** P < 0.01 and *** P < 0.001 vs. 2 m/o; #P < 0.05 and ##P < 0.01 vs. 14 m/o.