Research Paper Volume 13, Issue 6 pp 7800—7827

Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

Analysis of lymphoid populations in PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice by flow cytometry. (A) Percentage of Cd8+ (left) and Cd4+ (right) from Cd45+Cd3+ cells. (B) Linear regression between populations in NPCs and PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice. (C) Representative images of flow cytometry analysis. (D) Linear regression between Cd8+ cells (left) and Cd4+ cells (right) in PBMCs and the NAS score from 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 7-11 mice per group). Statistical analysis was performed by Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test. ** P vs. 2 m/o; #P vs. 14 m/o.

Figure 6. Analysis of lymphoid populations in PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice by flow cytometry. (A) Percentage of Cd8+ (left) and Cd4+ (right) from Cd45+Cd3+ cells. (B) Linear regression between populations in NPCs and PBMCs from 2 m/o, 14 m/o and 14 m/o + APAP mice. (C) Representative images of flow cytometry analysis. (D) Linear regression between Cd8+ cells (left) and Cd4+ cells (right) in PBMCs and the NAS score from 2 m/o, 14 m/o and 14 m/o + APAP mice. Data are represented as the mean ± S.E.M. (n = 7-11 mice per group). Statistical analysis was performed by Brown-Forsythe and Welch ANOVA test followed by their respective post-hoc test. ** P < 0.01 vs. 2 m/o; #P < 0.05 vs. 14 m/o.