Research Paper Volume 13, Issue 10 pp 13615—13625

The effect of IL-6/Piezo2 on the trigeminal neuropathic pain

The Piezo2 expression after anti-IL-6 administration. Immunocytochemistry imaged show the expression of Pieao2 in TN+saline group (A) and TN+anti-IL-6 group (B) at day 7, which accounts for 41.2±9.8% vs. 15.1±6.2% (pC). Three days after intraperitoneally administration of the anti-IL-6 in those trigeminal model rats, significant changes in mechanical threshold (D) as well as dynamic allodynia (E) and pinprick hyperalgesia scores (F) are observed.

Figure 7. The Piezo2 expression after anti-IL-6 administration. Immunocytochemistry imaged show the expression of Pieao2 in TN+saline group (A) and TN+anti-IL-6 group (B) at day 7, which accounts for 41.2±9.8% vs. 15.1±6.2% (p<0.05) (C). Three days after intraperitoneally administration of the anti-IL-6 in those trigeminal model rats, significant changes in mechanical threshold (D) as well as dynamic allodynia (E) and pinprick hyperalgesia scores (F) are observed.