Research Paper Volume 13, Issue 10 pp 13615—13625

The effect of IL-6/Piezo2 on the trigeminal neuropathic pain

The Piezo2 expression after IL-6 administration in the sham rats. Immunocytochemistry images show the expression of Pieao2 in Sham+saline (A) and Sham+IL-6 group (B) at day 7, which accounts for 19.8±6.1% vs. 35.2±9.2% (pC). Three days after local administration of recombinant rat IL-6 in those with sham operation, significant changes in mechanical threshold (D) as well as dynamic allodynia score (E) and pinprick hyperalgesia score (F) are observed.

Figure 8. The Piezo2 expression after IL-6 administration in the sham rats. Immunocytochemistry images show the expression of Pieao2 in Sham+saline (A) and Sham+IL-6 group (B) at day 7, which accounts for 19.8±6.1% vs. 35.2±9.2% (p<0.05) (C). Three days after local administration of recombinant rat IL-6 in those with sham operation, significant changes in mechanical threshold (D) as well as dynamic allodynia score (E) and pinprick hyperalgesia score (F) are observed.