Research Paper Volume 13, Issue 10 pp 13626—13643

E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer

Expression and methylation of E2F2 in GC tissues and normal tissues as revealed by bioinformatic analysis. (A) E2F2 expression levels in different tumor types from the TCGA database were detected by TIMER (*P **P ***P B and C) E2F2 mRNA is highly expressed in LGG tissues in GEPIA (B) dataset and Oncomine (C) dataset. (D) Kaplan-Meier analysis of survival rates of GC patients with high E2F2 expression and GC patients with low E2F2 expression.

Figure 1. Expression and methylation of E2F2 in GC tissues and normal tissues as revealed by bioinformatic analysis. (A) E2F2 expression levels in different tumor types from the TCGA database were detected by TIMER (*P < 0.05, **P < 0.01, ***P < 0.001). (B and C) E2F2 mRNA is highly expressed in LGG tissues in GEPIA (B) dataset and Oncomine (C) dataset. (D) Kaplan-Meier analysis of survival rates of GC patients with high E2F2 expression and GC patients with low E2F2 expression.