Research Paper Volume 13, Issue 8 pp 11907—11918

GEO data mining and TCGA analysis reveal altered branched chain amino acid metabolism in pancreatic cancer patients

MYC but not NOTCH mainly regulates BCAA uptake in myocyte of PDAC patients. (A–O): Data mining in GSE130563 dataset. (A–E) Gene expression of NOTCHs did not vary between groups while MYC was significantly up-regulated in muscles of cachectic PDAC patients. (F) Most of the SLC transporters exhibited no change except for SLC7A5 whose expression was slightly up-regulated in muscles of cachectic PDAC patients. (G–M) Gene expression of BCAA catabolism related genes in muscle. (N) In GSE130563 dataset, correlation analysis showed that SLC7A5 expression was in moderate correlation with MYC expression in muscle of PDAC patients (r = 0.639). (O) The relative fold-change of SLC7A5 expression in GSE62165 (tumor) and GSE102238 (tumor) were higher than that in GSE130563 (muscle).

Figure 5. MYC but not NOTCH mainly regulates BCAA uptake in myocyte of PDAC patients. (AO): Data mining in GSE130563 dataset. (AE) Gene expression of NOTCHs did not vary between groups while MYC was significantly up-regulated in muscles of cachectic PDAC patients. (F) Most of the SLC transporters exhibited no change except for SLC7A5 whose expression was slightly up-regulated in muscles of cachectic PDAC patients. (GM) Gene expression of BCAA catabolism related genes in muscle. (N) In GSE130563 dataset, correlation analysis showed that SLC7A5 expression was in moderate correlation with MYC expression in muscle of PDAC patients (r = 0.639). (O) The relative fold-change of SLC7A5 expression in GSE62165 (tumor) and GSE102238 (tumor) were higher than that in GSE130563 (muscle).