Research Paper Volume 13, Issue 7 pp 9373—9397

Differential role of melatonin in healthy brain aging: a systematic review and meta-analysis of the SAMP8 model

Forest plot comparing changes in the levels of cathepsins B and D between MT-treated and vehicle-treated groups. Compared with vehicle treatment, (A) cathepsin B and (B) cathepsin D levels were both significantly reduced in the MT-treated group. The unit for cathepsin B and cathepsin D are mU/mg, and U/mg, respectively. The prism represents the overall statistical results of the experimental data, squares represent the weight of each study, and horizontal lines represent the 95% CIs for each study. MT, melatonin; CI, confidence interval; SD, standard deviation; IV, independent variable.

Figure 7. Forest plot comparing changes in the levels of cathepsins B and D between MT-treated and vehicle-treated groups. Compared with vehicle treatment, (A) cathepsin B and (B) cathepsin D levels were both significantly reduced in the MT-treated group. The unit for cathepsin B and cathepsin D are mU/mg, and U/mg, respectively. The prism represents the overall statistical results of the experimental data, squares represent the weight of each study, and horizontal lines represent the 95% CIs for each study. MT, melatonin; CI, confidence interval; SD, standard deviation; IV, independent variable.