Research Paper Volume 13, Issue 8 pp 11942—11953

Activation of GPR30 with G1 inhibits oscillatory shear stress-induced adhesion of THP-1 monocytes to HAECs by increasing KLF2

Oscillatory shear stress (OSS) reduced the expression of GPR30 in human aortic endothelial cells (HAECs) in a time-dependent manner. HAECs were exposed to OSS (5 dyn/cm2) for various periods of times (6, 12, 24 h). (A). Expression of GPR30 at the mRNA level; (B). Expression of GPR30 at the protein level (*, #, $, P

Figure 1. Oscillatory shear stress (OSS) reduced the expression of GPR30 in human aortic endothelial cells (HAECs) in a time-dependent manner. HAECs were exposed to OSS (5 dyn/cm2) for various periods of times (6, 12, 24 h). (A). Expression of GPR30 at the mRNA level; (B). Expression of GPR30 at the protein level (*, #, $, P<0.01 vs. previous column group, N=5).