Research Paper Volume 13, Issue 8 pp 12007—12015

LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS

Overexpression of LINC00514 induced cell growth and EMT progression in GC cells. (A) The level of LINC00514 was overexpressed in SGC-7901 and HGC-27 cells after transfection with pcDNA-LINC00514. (B) Elevated expression of LINC00514 increased Ki-67 expression in both SGC-7901 and HGC-27 cells. (C) The expression of CDK2 in SGC-7901 and HGC-27 cells was measured by qRT-PCR. (D) Overexpression of LINC00514 induced cell growth in both SGC-7901 and HGC-27 cells. (E) Ectopic expression of LINC00514 inhibited E-cadherin expression and increased vimentin and N-cadherin expression. *p

Figure 3. Overexpression of LINC00514 induced cell growth and EMT progression in GC cells. (A) The level of LINC00514 was overexpressed in SGC-7901 and HGC-27 cells after transfection with pcDNA-LINC00514. (B) Elevated expression of LINC00514 increased Ki-67 expression in both SGC-7901 and HGC-27 cells. (C) The expression of CDK2 in SGC-7901 and HGC-27 cells was measured by qRT-PCR. (D) Overexpression of LINC00514 induced cell growth in both SGC-7901 and HGC-27 cells. (E) Ectopic expression of LINC00514 inhibited E-cadherin expression and increased vimentin and N-cadherin expression. *p<0.05, **p<0.01 and ***p<0.001.