Research Paper Volume 13, Issue 8 pp 12031—12045

Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats

LMV promoted bone formation of aged rats. (A) uCT of femurs from rats treated with LMV; (B) HE staining of femurs from rats treated with LMV; (C) Masson staining of femurs from rats treated with LMV; (D–G) Morphometric parameters of femurs obtained by uCT analysis, including BMD, Tb. BV/TV, Tb. N, Tb. Sp (x¯±s,n=6); (H) Tb. Ar obtained by bone histomorphometric staining analysis (x¯±s,n=6); (I, J) Serum ALP activity and TRAP activity detection. *P

Figure 9. LMV promoted bone formation of aged rats. (A) uCT of femurs from rats treated with LMV; (B) HE staining of femurs from rats treated with LMV; (C) Masson staining of femurs from rats treated with LMV; (DG) Morphometric parameters of femurs obtained by uCT analysis, including BMD, Tb. BV/TV, Tb. N, Tb. Sp (x¯±s,n=6); (H) Tb. Ar obtained by bone histomorphometric staining analysis (x¯±s,n=6); (I, J) Serum ALP activity and TRAP activity detection. *P < 0.05 vs. old female rats.