Research Paper Volume 13, Issue 8 pp 12046—12057

Hsa-miR-107 regulates chemosensitivity and inhibits tumor growth in hepatocellular carcinoma cells

MicroRNA-107 (miR-107) regulates tumor growth and tumor death in hepatocellular carcinoma (HCC) tumors in vivo. (A) The tumoral growth of HCC cell lines xenografted on nude mice. Treatment was administered at day 21 by tumor injection. (B) Hematoxylin and eosin (H&E)-stained sections from the xenograft. Scale bar: 100 μm. (C) TUNEL assay was performed to visualize apoptotic cells (green), and DAPI staining showed the number of nuclei. Scale bar: 100 μm. (D) Overexpression of miR-107 caused a decrease in CFL-1 and p-Akt expression both in two tumors as observed by western blotting assay.

Figure 5. MicroRNA-107 (miR-107) regulates tumor growth and tumor death in hepatocellular carcinoma (HCC) tumors in vivo. (A) The tumoral growth of HCC cell lines xenografted on nude mice. Treatment was administered at day 21 by tumor injection. (B) Hematoxylin and eosin (H&E)-stained sections from the xenograft. Scale bar: 100 μm. (C) TUNEL assay was performed to visualize apoptotic cells (green), and DAPI staining showed the number of nuclei. Scale bar: 100 μm. (D) Overexpression of miR-107 caused a decrease in CFL-1 and p-Akt expression both in two tumors as observed by western blotting assay.