Research Paper Volume 13, Issue 8 pp 12086—12098

Interferon regulatory factor transcript levels correlate with clinical outcomes in human glioma

Genetic alterations, co-expression, and interaction analysis of IRF family members in glioma patients. (A) Summary of genetic alterations in IRF family members in glioma. (B) OncoPrint visual summary of alterations in a query of IRF family members (cBioPortal). (C) Kaplan-Meier plot comparing overall survival in cases with/without IRF alterations (cBioPortal). (D) Correlation heat map of differentially expressed IRF family members in glioma (TCGA glioma dataset). (E) Protein-protein interaction network among the nine differentially expressed IRF family members (STRING). (F) Top 20 external genes functionally related to IRF family members and the interaction network (GeneMANIA).

Figure 5. Genetic alterations, co-expression, and interaction analysis of IRF family members in glioma patients. (A) Summary of genetic alterations in IRF family members in glioma. (B) OncoPrint visual summary of alterations in a query of IRF family members (cBioPortal). (C) Kaplan-Meier plot comparing overall survival in cases with/without IRF alterations (cBioPortal). (D) Correlation heat map of differentially expressed IRF family members in glioma (TCGA glioma dataset). (E) Protein-protein interaction network among the nine differentially expressed IRF family members (STRING). (F) Top 20 external genes functionally related to IRF family members and the interaction network (GeneMANIA).