Research Paper Volume 13, Issue 9 pp 12514—12525

Capsanthin induces G1/S phase arrest, erlotinib-sensitivity and inhibits tumor progression by suppressing EZH2-mediated epigenetically silencing of p21 in triple-negative breast cancer cells

Capsanthin delays cell-cycle progression in MDA-MB-231 cells. MDA-MB-231 cells synchronized at G1/S were treated with 10 μM capsanthin for 0, 3, 6, 9, 12 or 24 h, after which their cell-cycle stage was assessed by flow cytometry. *P **P ***P

Figure 2. Capsanthin delays cell-cycle progression in MDA-MB-231 cells. MDA-MB-231 cells synchronized at G1/S were treated with 10 μM capsanthin for 0, 3, 6, 9, 12 or 24 h, after which their cell-cycle stage was assessed by flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001. (Cap, capsanthin).