Research Paper Volume 13, Issue 9 pp 12526—12536

RO4929097 regulates RANKL-induced osteoclast formation and LPS-mediated bone resorption

RO4929097 suppresses osteoclastogenesis via Notch inhibition and the regulation of AKT phosphorylation. (A) RO4929097 treatment suppressed the expression of cleaved Notch1. (B) RO4929097 treatment suppressed the protein expression of Hes1 and NFATc1. (C) RO4929097 treatment suppressed the expression of AKT phosphorylation. The data were presented as the mean ± SD (*p **p ***p

Figure 4. RO4929097 suppresses osteoclastogenesis via Notch inhibition and the regulation of AKT phosphorylation. (A) RO4929097 treatment suppressed the expression of cleaved Notch1. (B) RO4929097 treatment suppressed the protein expression of Hes1 and NFATc1. (C) RO4929097 treatment suppressed the expression of AKT phosphorylation. The data were presented as the mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001).