Research Paper Volume 13, Issue 9 pp 12526—12536

RO4929097 regulates RANKL-induced osteoclast formation and LPS-mediated bone resorption

RO4929097 attenuated lipopolysaccharide-induced bone resorption in mouse knees in vivo. (A) Images of a three dimension reconstruction based on micro-CT scanning. (B) Results of BMD, bone BV/TV and Tb.n. (C, D and E) HE TRAP and ALP results. Amount of TRAP-positive OCs. The data are presented as the mean ± SD (*p **p ***p

Figure 5. RO4929097 attenuated lipopolysaccharide-induced bone resorption in mouse knees in vivo. (A) Images of a three dimension reconstruction based on micro-CT scanning. (B) Results of BMD, bone BV/TV and Tb.n. (C, D and E) HE TRAP and ALP results. Amount of TRAP-positive OCs. The data are presented as the mean ± SD (*p < 0.05; **p < 0.01; ***p < 0.001).