Research Paper Volume 13, Issue 8 pp 12160—12178

Balasubramide derivative 3C attenuates atherosclerosis in apolipoprotein E-deficient mice: role of AMPK-STAT1-STING signaling pathway

3C inhibits macrophage polarization and foam cell formation. (A) Fold change of iNOS, COX-2 and CD206 mRNA expression level. β-Actin was used for sample loading normalization. (B) 3C dose-dependently attenuate ox-LDL induced foam cell formation. (C) Quantification of the lipid disposition area versus the cellular area. All experiments were performed at least three times; were assessed using Student’s t-test and are present as mean±SEM. *P**P

Figure 4. 3C inhibits macrophage polarization and foam cell formation. (A) Fold change of iNOS, COX-2 and CD206 mRNA expression level. β-Actin was used for sample loading normalization. (B) 3C dose-dependently attenuate ox-LDL induced foam cell formation. (C) Quantification of the lipid disposition area versus the cellular area. All experiments were performed at least three times; were assessed using Student’s t-test and are present as mean±SEM. *P<0.05; **P<0.01.