Research Paper Volume 13, Issue 8 pp 12160—12178

Balasubramide derivative 3C attenuates atherosclerosis in apolipoprotein E-deficient mice: role of AMPK-STAT1-STING signaling pathway

3C inhibits JAK2/STAT1 and downstream signaling in AMPK dependent manner. (A) AMPKα inhibition with compound C attenuate the suppressive effect of 3C on STING-IRF3 signaling. (B, C) Quantification of the relative level of P-Stat1, P-AMPK, STING and P-IRF3 normalized to β-Actin (n=3 per group). The experiments were performed in triplicate and repeated at least three times on different days. Results are expressed as means ± SEM (n = 3). *P**P

Figure 7. 3C inhibits JAK2/STAT1 and downstream signaling in AMPK dependent manner. (A) AMPKα inhibition with compound C attenuate the suppressive effect of 3C on STING-IRF3 signaling. (B, C) Quantification of the relative level of P-Stat1, P-AMPK, STING and P-IRF3 normalized to β-Actin (n=3 per group). The experiments were performed in triplicate and repeated at least three times on different days. Results are expressed as means ± SEM (n = 3). *P<0.05, **P<0.01.