Research Paper Volume 13, Issue 9 pp 12552—12564

LncRNA NONMMUT055714 acts as the sponge of microRNA-7684-5p to protect against postoperative cognitive dysfunction

NONMMUT055714 and SORLA as binders of miR-7684-5p. (A) Predicted binding sites of miR-7684-5p to NONMMUT055714 and SORLA. (B) Dual-luciferase reporter experiments indicating NONMMUT055714 as a binder of miR-7684-5p. (C) The relative mRNA levels of NONMMUT055714 in the setting of miR-7684-5p overexpression. (D) SORLA as a potential target of miR-7684-5p. (E) Levels of SORLA protein in primary hippocampal nerve cells in the setting of miR-7684-5p overexpression. (F) Levels of SORLA mRNA in primary hippocampal nerve cells in the setting of miR-7684-5p overexpression. N = 3 from three independent experiment. Data represented as mean ± SD; * indicates p

Figure 3. NONMMUT055714 and SORLA as binders of miR-7684-5p. (A) Predicted binding sites of miR-7684-5p to NONMMUT055714 and SORLA. (B) Dual-luciferase reporter experiments indicating NONMMUT055714 as a binder of miR-7684-5p. (C) The relative mRNA levels of NONMMUT055714 in the setting of miR-7684-5p overexpression. (D) SORLA as a potential target of miR-7684-5p. (E) Levels of SORLA protein in primary hippocampal nerve cells in the setting of miR-7684-5p overexpression. (F) Levels of SORLA mRNA in primary hippocampal nerve cells in the setting of miR-7684-5p overexpression. N = 3 from three independent experiment. Data represented as mean ± SD; * indicates p < 0.05.