Research Paper Volume 13, Issue 9 pp 12565—12586

Investigation and verification of the clinical significance and perspective of natural killer group 2 member D ligands in colon adenocarcinoma

The differential expression and diagnostic ROC curves of NKG2DL genes in COAD. (A, B) The differential expression of NKG2DL genes in COAD: (A) Differential expression in the Edger and DESeq; (B) Expression distribution in TCGA; (C–J) The diagnostic ROC curves of NKG2DL genes in distinguish COAD tumor tissues and adjacent normal tissues in TCGA cohort: ROC curves of MICA (C); MICB (D); ULBP1 (E); ULBP2 (F); ULBP3 (G); RAET1E (H); RAET1G (I); RAET1L (J). Notes: COAD: colon adenocarcinoma; NKG2DL, Natural Killer Group 2 MemberD Ligand; ULBP: unique long 16 (UL16)-binding protein; MIC: Human Major Histocompatibility Complex (MHC) class I polypeptide-related sequence; TCGA: The Cancer Genome Atlas; NS: not significant; ROC: receiver operating characteristic; AUC: area under the curve; CI: confidence interval. * P

Figure 1. The differential expression and diagnostic ROC curves of NKG2DL genes in COAD. (A, B) The differential expression of NKG2DL genes in COAD: (A) Differential expression in the Edger and DESeq; (B) Expression distribution in TCGA; (CJ) The diagnostic ROC curves of NKG2DL genes in distinguish COAD tumor tissues and adjacent normal tissues in TCGA cohort: ROC curves of MICA (C); MICB (D); ULBP1 (E); ULBP2 (F); ULBP3 (G); RAET1E (H); RAET1G (I); RAET1L (J). Notes: COAD: colon adenocarcinoma; NKG2DL, Natural Killer Group 2 MemberD Ligand; ULBP: unique long 16 (UL16)-binding protein; MIC: Human Major Histocompatibility Complex (MHC) class I polypeptide-related sequence; TCGA: The Cancer Genome Atlas; NS: not significant; ROC: receiver operating characteristic; AUC: area under the curve; CI: confidence interval. * P<0.05; *** P<0.001; **** P<0.0001.