Research Paper Volume 13, Issue 9 pp 12766—12779

Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth

DDX49 expression and its effects on HCC xenografts in mice and HCC in patients. (A, B) QGY-7703 cells were transfected with DDX49-shRNA or negative-control shRNA, then injected into nude mice (N=8 animals/group). Control mice were nude mice inject with tumor cells. Scale bar, 1 cm. After 6 weeks, tumor volume was measured. (C) DDX49 expression in HCC patients was used to differentiate tumor tissue and normal liver tissue. (D, E) Western blot analysis of DDX49 in paired samples of tumor and normal liver tissue from HCC patients. *P

Figure 4. DDX49 expression and its effects on HCC xenografts in mice and HCC in patients. (A, B) QGY-7703 cells were transfected with DDX49-shRNA or negative-control shRNA, then injected into nude mice (N=8 animals/group). Control mice were nude mice inject with tumor cells. Scale bar, 1 cm. After 6 weeks, tumor volume was measured. (C) DDX49 expression in HCC patients was used to differentiate tumor tissue and normal liver tissue. (D, E) Western blot analysis of DDX49 in paired samples of tumor and normal liver tissue from HCC patients. *P < 0.01 compared to the control group.