Research Paper Volume 13, Issue 9 pp 12780—12799

CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis

Molecular mechanism underlying the role of circRNA

Figure 11. Molecular mechanism underlying the role of circRNA_30032 in TGF-β1-induced renal fibrosis. TGF-β1 induces expression of circRNA_30032 via p38 MAPK signaling pathway. CircRNA_30032 promotes renal fibrosis by sponging miR-96-5p and subsequently increasing the expression of HBEGF and KRAS.