Research Paper Volume 13, Issue 9 pp 12800—12816

Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture

Decreased presence of ADAMTS-5 within the aneurysmal wall. (A) Representative immunofluorescence performed on intracranial aneurysm samples harvested from human IA patients after microsurgical clipping, and the normal cerebral artery harvested from a human brain trauma patient, showing the presence of ADAMTS-5. ADAMTS-5 and Collagen IV are displayed in red and green, respectively. Scale bars: 20 μm. (B) CTA identification of aneurysms from the patients included in this study. Human IA sample 1 and sample 2 were obtained from IA patient 1 and patient 2, respectively. (C, D) Representative immunofluorescence performed on mouse samples displaying the healthy control artery and aneurysmal artery for ADAMTS-5. Scale bars: 20 μm. ATS5, ADAMTS-5; COLL IV, Collagen IV.

Figure 1. Decreased presence of ADAMTS-5 within the aneurysmal wall. (A) Representative immunofluorescence performed on intracranial aneurysm samples harvested from human IA patients after microsurgical clipping, and the normal cerebral artery harvested from a human brain trauma patient, showing the presence of ADAMTS-5. ADAMTS-5 and Collagen IV are displayed in red and green, respectively. Scale bars: 20 μm. (B) CTA identification of aneurysms from the patients included in this study. Human IA sample 1 and sample 2 were obtained from IA patient 1 and patient 2, respectively. (C, D) Representative immunofluorescence performed on mouse samples displaying the healthy control artery and aneurysmal artery for ADAMTS-5. Scale bars: 20 μm. ATS5, ADAMTS-5; COLL IV, Collagen IV.