Figure 2. Effects of recombinant protein ADAMTS-5 on the development of aneurysmal rupture in male mice. (A) Incidence of aneurysm and rupture rate in sham mice, control (CTRL) IA mice, and recombinant protein ADAMTS-5-administered (rADAMTS-5) IA mice. (B) Symptom-free curve (Kaplan-Meier analysis curve) demonstrated a significant increase in survival in the rADAMTS-5 treatment cohort (log-rank P<0.05). (C) Unruptured aneurysm. (D) No aneurysm. (E) Ruptured aneurysm. *P<0.05, **P<0.01.