Research Paper Volume 13, Issue 9 pp 12865—12895

Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma

Kaplan–Meier curves for overall survival of the 10 selected hub genes and construction of a prognostic signature using LASSO Cox regression. (A) OS Kaplan–Meier curves of the 10 hub genes based on ICGC-LIRI-JP. (B) 10-fold cross-validation to select the optimal tuning parameter. The λ value of 0.015 was chosen with the lambda.min method. (C) LASSO coefficient profiles of the 10 hub genes. (D) Forest plot presenting the hazard ratio and 95% CI by multivariate Cox regression analysis for the four selected hub genes. OS, overall survival. LASSO, Least absolute shrinkage and selection operator. 95% CI, 95% confidence interval.

Figure 8. Kaplan–Meier curves for overall survival of the 10 selected hub genes and construction of a prognostic signature using LASSO Cox regression. (A) OS Kaplan–Meier curves of the 10 hub genes based on ICGC-LIRI-JP. (B) 10-fold cross-validation to select the optimal tuning parameter. The λ value of 0.015 was chosen with the lambda.min method. (C) LASSO coefficient profiles of the 10 hub genes. (D) Forest plot presenting the hazard ratio and 95% CI by multivariate Cox regression analysis for the four selected hub genes. OS, overall survival. LASSO, Least absolute shrinkage and selection operator. 95% CI, 95% confidence interval.