Research Paper Volume 13, Issue 9 pp 12919—12928

Knockdown of ZFAS1 improved the cardiac function of myocardial infarction rats via regulating Wnt/β-catenin signaling pathway

Inhibition of Wnt/β-catenin pathway remarkably reversed the influence of shZFAS1 on cardiac function. (A) Influence of XAV939 on the histological changes of MI rats myocardial tissues (Scale bar = 500 μm). (B) Influence of XAV939 on the collagen deposition of MI rats myocardial tissues (Scale bar = 500 μm). (C) Influence of XAV939 on the infarction ratio of MI rats myocardial tissues. (D) The expression of vWF in the MI rats myocardial tissues was measured using IHC staining (Scale bar = 500 μm). (E) Influence of XAV939 on the vWF expression in the MI rats myocardial tissues. (F) Influence of XAV939 on the left ventricular fractional shortening of MI rats. (G) Influence of XAV939 on the left ventricular ejection fraction of MI rats. *P #P

Figure 4. Inhibition of Wnt/β-catenin pathway remarkably reversed the influence of shZFAS1 on cardiac function. (A) Influence of XAV939 on the histological changes of MI rats myocardial tissues (Scale bar = 500 μm). (B) Influence of XAV939 on the collagen deposition of MI rats myocardial tissues (Scale bar = 500 μm). (C) Influence of XAV939 on the infarction ratio of MI rats myocardial tissues. (D) The expression of vWF in the MI rats myocardial tissues was measured using IHC staining (Scale bar = 500 μm). (E) Influence of XAV939 on the vWF expression in the MI rats myocardial tissues. (F) Influence of XAV939 on the left ventricular fractional shortening of MI rats. (G) Influence of XAV939 on the left ventricular ejection fraction of MI rats. *P < 0.05 compared with the group sham. #P < 0.05 compared with the group MI.