Research Paper Volume 13, Issue 8 pp 10955—10972

Hyperbaric oxygen therapy effectively alleviates D-galactose-induced-age-related cardiac dysfunction via attenuating mitochondrial dysfunction in pre-diabetic rats

Effect of HBOT on cardiomyocytes apoptosis, inflammation and oxidative stress in pre-diabetic rats after induction of aging by D-gal. (A) Bax/Bcl-2 ratio. (B) Cleaved caspase-3/caspase-3 ratio. (C) Inflammation. (D) Oxidative stress. NDV, normal diet fed rats with vehicle; NDDg, normal diet fed rats with D-gal; HFV, high-fat diet fed rats with vehicle; HFDg, high-fat diet fed rats with D-gal; Bax, B-cell lymphoma 2 associated X protein; Bcl-2, B-cell lymphoma 2; TNF-α, tumor necrosis factor alpha; MDA, malondialdehyde; HBOT, hyperbaric oxygen therapy. (n = 5/group). *P

Figure 6. Effect of HBOT on cardiomyocytes apoptosis, inflammation and oxidative stress in pre-diabetic rats after induction of aging by D-gal. (A) Bax/Bcl-2 ratio. (B) Cleaved caspase-3/caspase-3 ratio. (C) Inflammation. (D) Oxidative stress. NDV, normal diet fed rats with vehicle; NDDg, normal diet fed rats with D-gal; HFV, high-fat diet fed rats with vehicle; HFDg, high-fat diet fed rats with D-gal; Bax, B-cell lymphoma 2 associated X protein; Bcl-2, B-cell lymphoma 2; TNF-α, tumor necrosis factor alpha; MDA, malondialdehyde; HBOT, hyperbaric oxygen therapy. (n = 5/group). *P < 0.05.