Research Paper Volume 13, Issue 10 pp 13788—13806

Redd1 knockdown prevents doxorubicin-induced cardiac senescence

Modulation of Redd1 expression impacts Dox-induced cardiac alterations in vivo. (A) Representative echocardiography photographs depicting left ventricular function in the different groups of mice. (B–E) Analysis of the effects of Redd1 overexpression and knockdown on parameters of cardiac function in Dox-treated mice (n = 6–8 per group). (F) Effect of Redd1 overexpression and knockdown on cardiac fibrosis induced by Dox administration in vivo, as determined by Masson’s trichrome staining. (G) Quantitative analysis of Masson’s trichrome staining results (n = 6–8 per group). Data are mean ± SEM. *p &p

Figure 7. Modulation of Redd1 expression impacts Dox-induced cardiac alterations in vivo. (A) Representative echocardiography photographs depicting left ventricular function in the different groups of mice. (BE) Analysis of the effects of Redd1 overexpression and knockdown on parameters of cardiac function in Dox-treated mice (n = 6–8 per group). (F) Effect of Redd1 overexpression and knockdown on cardiac fibrosis induced by Dox administration in vivo, as determined by Masson’s trichrome staining. (G) Quantitative analysis of Masson’s trichrome staining results (n = 6–8 per group). Data are mean ± SEM. *p < 0.05 vs. the AAV9-NC group. &p < 0.05 vs. the AAV9-shNC group.